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But while it may be the third, its also the first of its kind in the GLP-1 class of drugs

It is primarily manifested by increased intracellular iron levels and enhanced lipid peroxidation, ultimately leading to cell death characterized by mitochondrial shrinkage, loss of cristae, and disruption of membrane integrity ( The Gut Microbiota, as a vital component of the intestinal microenvironment, plays a pivotal role in maintaining intestinal homeostasis, modulating host immune responses, participating in metabolic regulation, and promoting nutrient absorption

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We used 3 nmol kg 1 of tirzepatide, identified as a maximal dose for glucose lowering in wild-type mice (Extended Data Fig